The Spanish soccer league La Liga ends this weekend with Round 38 to be played from Friday, May 21 to Sunday, May 23. The title race will finally be put to rest with Atletico Madrid being only an inch away from confirming their first Spanish league title since 2013-14. Real Madrid will be hoping they slip up but they must win in order to overcome their arch-rivals. In the third are Barcelona, followed by Sevilla in the fourth position.

In the final Round 38, leaders Atletico travel to Valladolid on Saturday, May 22, in one last attempt to become the official champions. The same day, at the same time, Real Madrid will face Villarreal while dreaming of crushing Atleti's dreams to reach the La Liga title. In addition, third-placed Barcelona will try to keep their position as they play bottom side Eibar away.

This round provides an opportunity for the bettor to play around with parlays, picks in the over/under, or goalscorers. Here are some betting predictions to consider when placing a bet on these La Liga matchups.

Real Valladolid vs Atletico Madrid betting picks (Saturday, May 22)

Atletico Madrid will have only themselves to blame if they lose here, and thus, lose the La Liga trophy after being on top of the table for several months now. This is their last chance to write their own destiny, and their only choice is to grab a win in Valladolid. However, they should be aware of their final obstacle, as Real Valladolid still have a chance to avoid relegation, so they would have something worth fighting for.

It is the favorites Atletico who are at -320 to win this clash while the wager on Valladolid is at +700. Taking into consideration the risk that both sides have put, betting that the matchup ends in a 3-1 win for the away side, for example, is paying out +950 if you want to bet on the clash, as it might be much more interesting than an outright bet. At $100, the bettor could earn $950. If you got to pick anyone to put the ball in the back of the net in this game look no further than Luis Suarez, as he is at +210 to be the first one to score.

Real Madrid vs Villarreal betting picks (Saturday, May 22)

Depending on Atletico Madrid's clash with Valladolid, this will certainly be the ultimate "do or die" matchup for Real Madrid. If they win and their city rivals fail to do so, the Whites will be crowned the new Spanish champions for the second time in two years. Villarreal are +600 underdogs, and while they did beat Sevilla unexpectedly in Round 37, the oddsmakers don't see the Yellow Submarine repeating the same success.

An interesting fact is that Real Madrid have not lost a single league fixture since January 30, when they were surprised by Levante 2-1. They most certainly will look to continue that impressive run, even though destiny is not in their hands. As a result, the Madrid side are at -250 to win this matchup while the wager. Betting that the clash ends in a 1-0 victory for the home side, for example, is paying out +900, if you want to bet on the clash, might be much more interesting than an outright bet. At $100, the bettor could earn $900. If you got to pick anyone to put the ball in the back of the net in this game look no further than Karim Benzema, as he is at +230 to be the first one to score.

Eibar vs Barcelona betting picks (Saturday, May 22)

Eibar are +370 underdogs, mostly because of their poor performances in the La Liga 2021-22 season. They sit at the bottom of the table, but they still have the chance to say in the Spanish top flight. It is the hosts who have a lot to lose, even though they are halfway in Segunda Division. In case the Basque club beat Barcelona, and Valladolid, Elche, and Huesca all fail to win, Eibar would mathematically not get relegated. 

Meanwhile, Barcelona have only the third spot to lose if Sevilla in the last round, but it would not make any difference to them as the Blaugrana have already lost the title race, but have qualified for the Champions League next season. FanDuel believe that Barca will justify the odds, as they are at -165 to win away. With Lionel Messi not being called up for the game, and if we have Eibar's situation in mind, perhaps betting that the game ends in a 1-0 win for the hosts might sound like a risky bet but it could turn out to be very rewarding later. At +2500, a $100 bet could earn the bettor $2,500.

Parlays for these three matchups of La Liga Round 38

A solid parlay bet could be the following: Atletico Madrid to beat Real Valladolid 3-1; Luis Suarez to be the one to open the score; the Real Madrid vs Villarreal clash to end in a final result of 1-0; Karim Benzema to score the first goal, and Eibar to upset Barcelona 1-0 at home. At $50, the bettor could win up to $2,395.

Want to stay in the know about all La Liga fixtures and betting options? Don’t miss a single detail on one of the most prestigious soccer leagues in the world and its possible contenders, Atletico Madrid or Real Madrid, thanks to our betting articles right here at Bolavip!