Manchester Unitedwill welcomeAston Villaat the Old Trafford in Manchesterin the sixth round of the2021-22 Premier League seasonon Saturday, September 25, 2021, at 7:30AM (ET).Here, you will find the expected lineups of both teams that will appear inMatchday 6of thePremier League.

This will be their53rd EPL meeting.There are no surprises here asManchester Unitedare the firm favorites in head-to-head clashes, having celebrated a victory on37occasionsso far;Aston Villahave grabbed a triumph just three timesto this day, and a great number of even12matcheshave ended in a draw.

Their most recent game was played on May 9, 2021, when the Red Devils smashed the Claret & Blue Army with a final result of 3-1 away at Villa Park in Birmingham in the 2020/21 Premier League season. It promises to be a more exciting clashas they meet for the first time in the new2021/2022 Premier League season.

Manchester United probable lineup

Marcus Rashford and Amad Diallo will be absent again for Manchester Uniteddue to injury, while Edinson Cavani will have to fight for a starting spot after just returning to first-team training recently. Norwegian coach Ole Gunnar Solskjaer is likely to make 11 changes from last weekend’s EFL Cup defeat to West Ham, and it would not be surprising to see the same lineup as last weekend’s league match against the Hammers.

Thus, Paul Pogba is expected to take his placeon the left flank, with Scott McTominay and Fred in midfield, and Mason Greenwood and Bruno Fernandes behindRonaldo. New arrival Jadon Sancho has struggled to make an impact so far and he is set to come off the bench against the Villa.

Manchester United possible starting XI:
De Gea; Wan-Bissaka, Varane, Maguire, Shaw; Fred, McTominay; Greenwood, Fernandes, Pogba; Ronaldo.

Aston Villa probablelineup

Axel Tuanzebe is unable to play against his former club, while Trezeguet, Kein Davis, and Morgan Sanson are all injured and will miss the match in Manchester. After suffering aninjury, Matt Targett is also questionable, while John McGinn and Bailey are fighting to be available due to concussions and thigh issues, respectively.

If Targett is unavailable, the visitors may play in a 3-5-2 system again, with Kortney Hause replacing Tuanzebe. Ex-United captain Ashley Young could also start if Tuanzebe is unavailable.Villa, on the other hand, should have plenty of ammunition, with Danny Ings and Ollie Watkins likely to begin as the front two, suggesting that Emiliano Buendia may have to settle for a bench berth.

Aston Villa possible starting XI:
Martinez; Mings, Hause, Konsa; Cash, Luiz, Nakamba, Ramsey, Young; Ings, Watkins.