Tottenham and Manchester United will square off at theTottenham Hotspur Stadium in London in the 10th round of the 2021-22 Premier League season on Sunday, October 24, 2021, at 11:30 AM (ET). Here, you will find the expected lineups of both teams that will appear in thisMatchday 10derby soccer gameof the English Premier League.

This will be their 59th EPL meeting. No surprises here as Manchester United have been the absolute favorites in head-to-head duels, triumphingin 36 games so far; Tottenham Hotspur have celebrated a victory 10 times to this day, and the remaining 12 matches have ended in a draw so far.

Their most recent game was played on April 11, 2021, when the Red Devils cruised past the Spurs with a final result of 3-1away in London in a 2020/2021 Premier League match. It promises to be an even more exciting clash in the new 2021/2022 Premier League season.

Tottenham probablelineup

Tottenham will be without Ryan Sessegnon, who has been out with a long-term hamstring injury, while Bryan Gil, who picked up a thigh injury against Burnley in the EFL Cup on Wednesday, is unlikely to play. Nuno Espirito Santo has no additional injury worries at this time, and the manager may opt to pitch the same lineup that faced West Ham at the weekend.

Kane and Son Heung-min are expected to start in the last third of the pitch, with Lucas Moura and Tanguy Ndombele joining them in midfield.

Tottenham possible starting XI:
Lloris; Emerson, Romero, Dier, Reguilon; Skipp, Hojbjerg; Lucas, Ndombele, Son; Kane.

Manchester United probable lineup

Manchester United will almost certainly start David de Gea in goal, but given their dismal performance against Liverpool last time, anticipate some changes in the defense. If fit for the forthcoming game, Raphael Varane will replace Victor Lindelof on the teamsheet, partnering Harry Maguire in the four-man backline, with Luke Shaw and Aaron Wan-Bisaaka on the flanks.

With Paul Pogba suspended following his red card on Sunday, Nemanja Matic is likely to fill the defensive midfield role. Despite recent rumors, it is impossible to envisage Bruno Fernandes and Cristiano Ronaldo being dropped from the starting XI. Edinson Cavani and Jesse Lingard are also candidates for change. Both Anthony Martial and Amad Diallo will be hoping to be included in the team after recovering from injuries in time for the match.

Manchester United possible starting XI:
De Gea; Wan-Bissaka, Varane, Maguire, Shaw; Matic, Fred; Sancho, Fernandes, Rashford; Ronaldo.