Once again CONMEBOL World Cup qualifying is off and running with 5 games that will have soccer fans at the edge of their seats in matchday 11. The marquee matches for this round is Uruguay - Colombia and Peru - Chile.

Argentina and Brazil have two very winnable games, while Ecuador will look to bounce back from a tough defeat to Uruguay against Bolivia. The oddsmakers at DraftKings have put out the odds and we have laid out the best picks for matchday 11’s games.

Brazil is still undefeated in qualification and Argentina are a firm second place. Places 3-6 is up for grabs and when it’s all said and done the table may look dramatically different. Here are the best picks for matchday 11 of CONMEBOL World Cup qualifying.

Uruguay - Colombia

Wilmar Barrios of Colombia (Getty)

Wilmar Barrios of Colombia (Getty)

In one of the marquee matches of matchday 11 Uruguay (+110) comes into their match against Colombia (+295) riding on a high after their defeat of Ecuador, while Colombia scored a huge win against Chile. Look for Uruguay to play a tight game and a counter attacking style against Colombia who could upset Uruguay in El Gran Parque Central. A draw is not out of the question at +220.

Paraguay - Argentina

Lionel Messi of Argentina competes for the ball with Ángel Cardozo (L), Santiago Arzamendia and Richard Sanchez (R) of Paraguay (Getty)

Lionel Messi of Argentina competes for the ball with Ángel Cardozo (L), Santiago Arzamendia and Richard Sanchez (R) of Paraguay (Getty)

It’s a tough match for Paraguay (+475) as they will face Argentina (-145) at home but look for it to be an uphill battle for Paraguay. Argentina is riding high and with their firepower up top and their morale at an all-time high, Argentina should take this one.

Venezuela - Brazil

Neymar Jr. of Brazil (Getty)

Neymar Jr. of Brazil (Getty)

After the mess that was the Brazil- Argentina match, Brazil (-290) will look to get back to winning ways, they are still undefeated, and will face lowly Venezuela (+850), who even at home should not be a difficult challenge for Brazil.

Ecuador - Bolivia

Fidel Martinez of Ecuador runs for the ball during an international friendly between Ecuador and Bolivia (Getty)

Fidel Martinez of Ecuador runs for the ball during an international friendly between Ecuador and Bolivia (Getty)

Bolivia (+1700) may be a tough opponent but they also need to start winning to climb the standings. Ecuador (-700) who was a handful for Uruguay and only lost that match late in the game will look to bounce back with 3 must win points. El Tricolor looks to be a much more polished side and will most likely take this match.

Peru - Chile

André Carrillo of Peru fights for the ball with Mauricio Isla of Chile (Getty)

André Carrillo of Peru fights for the ball with Mauricio Isla of Chile (Getty)

This is one of the biggest matches of the day in CONMEBOL World Cup qualifying, both Peru (+160) and Chile (+190) cannot afford to lose any more points, one of these teams needs to get a win and while Chile is away from home Peru looks like the more dangerous side. Look for Peru to finally get three points.