The Copa CONMEBOL Libertadores 2021 Group Stage will conclude this weekend and Santos face their last opportunity to fight for a place in the last 16 in their visit to Barcelona de Guayaquil today at the Estadio Monumental Isidro Romero Carbo. The Brazilian side must avoid losing to keep its hopes alive, while the hosts have already booked their ticket to the next round. Here, check out the match information, storylines, predictions, odds, and how to watch it in the US.

Fabián Bustos' boys have had a surprising performance in Group C and have progressed to the Round of 16 with one game left. The Ecuadorian champs, however, haven't secured the first place yet, which they'll try to do in the upcoming match.

For the runners-up of the last Libertadores, though, this game is much more significant. Fernando Diniz's side is at risk of being eliminated unless it wins and other results help it to finish second. The Peixe don't face an easy challenge, but it will be their last opportunity to finally step up.

Barcelona SC vs Santos: Match Information

Date: Wednesday, May 26, 2021
Time: 8 PM (ET)
Location: Estadio Monumental Isidro Romero Carbo, Guayaquil

Barcelona SC vs Santos: Time by State in the US

ET: 8 PM
CT: 7 PM
MT: 6 PM
PT: 5 PM

Barcelona SC vs Santos: Storylines

Before the beginning of the tournament, few could have expected Barcelona de Guayaquil to be ruling Group C at this point. Against all odds, the Canarios have had a strong start with three straight wins and head to the group finale comfortably.

Last week, Fabián Bustos' side tied with Boca Juniors at La Bombonera and clinched a Round of 16 berth. Whether or not Barcelona finish first is yet to be seen, though. Their next rivals find themselves in a tough spot, however, turning this into a thrilling Libertadores night.

Santos have gone through a rough patch as Ariel Holan stepped away in the middle of the tournament, and even though they've suddenly grabbed two important wins in Matchday 4 and 5, a shocking defeat at the hands of The Strongest last week put their top-two finish in jeopardy. To surpass Boca, they'll need to win or at least tie against Barcelona and hope that the Xeneize don't beat the Bolivian side.

Barcelona SC vs Santos: Copa Libertadores 2021 Standings

After Matchday 5, Barcelona de Guayaquil are atop Group C with ten points, while Santos sit third with six points, as much as The Strongest, but above them due to goal difference. Boca are currently holding the second seed with only one point more than the Peixe.

How to watch or live stream Barcelona SC vs Santos in the US

Copa Libertadores 2021 Group C Matchday 6 duel between Barcelona de Guayaquil and Santos at Estadio Monumental Isidro Romero Carbo will be broadcast in the US by Fanatiz.

Barcelona SC vs Santos: Predictions and Odds

Bookmakers haven't placed their bets yet. However, Caliente did and it sees Barcelona de Guayaquil as favorites with odds of +120, while Santos were given +225, and a tie would result in a +230 payout.

  Caliente
Barcelona SC +120
Tie +230
Santos +225

* Odds via Caliente.