Once again, the big Argentine derby is looming around. Boca Juniors and River Plate face off in the Argentine Copa de la Liga Profesional 2021 quarterfinals at the iconic La Bombonera. A new Superclásico has every soccer fan on the continent eager to see who will move forward in their quest towards the trophy. Here, you'll find everything there is to know about this game, such as the match information, storylines, predictions, odds, and how to watch it in the US.

The Xeneizes will be seeking redemption against their lifelong rivals, who were dominant against them in recent years. Miguel Angel Russo's boys comfortably earned a spot in this knockout stage, and they'll want to finally beat El Millonario at home. The last time Boca won the derby at La Bombonera for an Argentine League game was in 2015.

Meanwhile, Marcelo Gallardo's team heads into this clash looking to extend its great streak against the archrivals. River have secured their place in this round last weekend when they put four past Aldosivi at Estadio Monumental. Their last visits to La Boca ended in draws, but this time there has to be a winner.  Will River claim the Superclásico once again?

Boca Juniors vs River Plate: Match Information

Date: Sunday, May 16, 2021
Time: 4:30 PM (ET)
Location: La Bombonera, Buenos Aires

Boca Juniors vs River Plate: Time by State in the US

ET: 4:30 PM
CT: 3:30 PM
MT: 2:30 PM
PT: 1:30 PM

Boca Juniors vs River Plate: Storylines and Head-to-Head

Boca Juniors have had some ups and downs in the group stage, but a string of good results in the final weeks allowed them to seal a place in the quarterfinals. However, Russo's side has been struggling in the Copa Libertadores recently, as it lost in the last two rounds. They're not at their best to face the upcoming clash, but it may be a good opportunity for the Xeneize to wake up.

On the other hand, River Plate head to this clash after earning a dramatic draw in their visit to Junior in a controversial game because of the chaotic situation in Colombia. In the domestic tournament, El Millonario's last game saw them destroy the modest Aldosivi to get into the best eight of the Copa de la Liga. Gallardo's boys struggled to be consistent this year. The one who wins this game, though, will be probably seen as the frontrunners for the title.

Needless to say, these two have an extremely long history facing each other in the so-called Superclásico of Argentine soccer. In the professional era, they've clashed 202 times, with Boca Juniors winning 74 of them, while River Plate claimed the victory in 65 games, and they've tied in 63 duels.

Boca Juniors vs River Plate: Copa de la Liga Profesional 2021 Standings

Both made it to the top four to get into this stage. Boca Juniors finished second in Group B with 22 points, while River Plate sat third in Group A with 21 points.

Boca Juniors vs River Plate: Copa de la Liga Profesional 2021 Top Scorers

Boca Juniors' top scorer is Sebastián Villa, who has four goals this season. Meanwhile, Rafael Santos Borré is not only River Plate's goalscorer but the tournament's as well, as he has been on target eight times.

Will we see Rafael Santos Borré on target again? (Getty)

How to watch or live stream Boca Juniors vs River Plate in the US

The Argentine Superclásico between Boca Juniors and River Plate to be played at La Bombonera in the Copa de la Liga Profesional 2021 quarterfinals will be broadcast in the US by FanatizParamount+, and TyC Sports Internacional.

Boca Juniors vs River Plate: Predictions and Odds

Oddsmakers in the US have already made their predictions for this game, and they believe Gallardo's boys will upset the Xeneizes once again. DraftKings has given River Plate odds of +130, while Boca Juniors have +210, and a tie would result in a +200 payout.

Boca Juniors +210
Tie +200
River Plate +130

* DraftKings.