Paris Saint-Germain coach Mauricio Pochettino made a totally crazy move in Sunday's match against Lyon. The guests took the lead in the match thanks to Lucas Paqueta's goal in the 54th minute, and PSG equalized through Neymar from the penalty spot in the 66th minute.

Then, in the moments when the Parisians were chasing a goal for the win, the Argentine coach pulled off a very risky, but it eventually proved to be a rewarding move. He decided to take Lionel Messi out of the game and replace him with right-back Achraf Hakimi. 

The superstar forward could not believe what was happening and while he was leaving the field, he looked at Pochettino, made a comment about the decision, and refused to shake hands with the 49-year-old boss. Eventually, Pochettino got lucky as Mauro Icardi scored late in the extra time, so the Red and Blue came to victory, triumphing 2-1 in Round 6 in the grand derby away against Lyon.

Messi refuses to shake Pochettino's hand after being subbed off: Funniest memes and reactions

Many fans of PSG, Messi, and soccer in general, took to social media to share their reactions to coach Pochettino opting to replace the 34-year-old's and ending up empty-handed. So let's take a look at some of the funniest memes and reactions.