The San Francisco 49ers host the Denver Broncos in Week 1 of the 2025 NFL preseason. Will stars Christian McCaffrey and Bo Nix see any action in today’s game, or will they be benched?
Ahead of the 2025 NFL season, both the 49ers and Broncos are viewed as potential contenders. Each club has built a strong roster in recent years, supported by coaching staffs that have worked exceptionally well to put their franchises back in the spotlight.
On Thursday, the two teams held a joint practice ahead of their official matchup on Saturday. It will be the final game of the day, with many fans eager to see what these two historic franchises can deliver tonight.
Is Christian McCaffrey playing for the 49ers against the Broncos today?
One of the big questions for the 49ers heading into the season is whether Christian McCaffrey is fully healthy. After dealing with multiple injuries last year, the star running back is set to start the 2025 season, but his preseason status remains uncertain.

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Following Achilles tendinitis in both legs last year, the 49ers are not willing to risk any further injury to McCaffrey. For that reason, the running back is not expected to play in today’s game against the Broncos.
Will Bo Nix play in the preseason opener against the 49ers?
On the other hand, Broncos quarterback Bo Nix is expected to see some action tonight against San Francisco. Head coach Sean Payton confirmed that the starters will get some playing time, though not for the entire game.

Bo Nix, star quarterback for the Denver Broncos
Nix is the undisputed starter in Denver, and Payton wants to get him into rhythm to avoid a slow start to the season, something the second-year quarterback experienced in his rookie campaign.
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