The <a href="https://bolavip.com/en/topic/san-francisco-49ers">San Francisco 49ers</a> face the Chicago Bears in Week 17 of the NFL regular season in a matchup that could define their future and determine whether they can fully meet their objectives for the 2025 campaign.



The path for the San Francisco 49ers to secure the No. 1 seed in the NFC playoff picture is simple: win their final two games of the regular season. The first and most critical step comes Sunday night at Levi’s Stadium against the 11-4 Chicago Bears, a result that would keep San Francisco firmly in control of its postseason destiny.



The 49ers already clinched a playoff berth last week after Detroit lost to Pittsburgh. They currently sit one game behind Seattle and remain tied with Los Angeles in the NFC West. If the 49ers defeat the Bears and then Seattle in Week 18, they claim both the division title and the No. 1 seed in the conference.



<h2>What happens if the 49ers lose vs Bears?</h2>



If the 49ers lose to the <a href="https://bolavip.com/en/topic/chicago-bears">Bears</a>, their margin for error shrinks significantly. They could still win the division, but they would now need additional help after Seattle’s 27–10 victory over Carolina, along with a Los Angeles loss to Atlanta, before handling business in Week 18. This matchup also serves as the head-to-head tiebreaker between both teams.



<figure class="wp-block-gallery has-nested-images columns-default is-cropped">
<figure class="wp-block-image size-large"><figure class="image"><img loading="lazy" width="1920" height="1080" data-id="512485" src="https://ds-images.bolavip.com/news/image?src=https://images.bolavip.com/webp/en/full/BUS_20251229_BUS_553177_caleb-williams_f40f0d6d.webp&amp;width=1920&amp;height=1080" alt="Caleb Williams Chicago Bears" class="wp-image-512485" sizes="(max-width: 1920px) 100vw, 1920px"></figure><figcaption>Caleb Williams #18 of the Chicago Bears.</figcaption></figure>
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From a postseason standpoint, there is no immediate panic. San Francisco already secured a playoff spot, so elimination is not a concern. Both teams enter the matchup with identical 11-4 records, and the 49ers are slight home favorites in what projects as a tightly contested game.


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<h2>The 49ers’ main objective</h2>



The goal for San Francisco is clear and ambitious: securing the No. 1 seed in the NFC. That position guarantees a first-round bye and home-field advantage throughout the playoffs, a massive edge during January football at Levi’s Stadium.



The destiny remains entirely in San Francisco’s hands. Winning out eliminates the need to monitor other results around the league. The immediate challenge is Chicago, a young and talented team capable of capitalizing on mistakes and creating problems if given momentum.



<h2>What the 49ers must do to win</h2>



Brock Purdy plays his best football at the most important moment of the <a href="https://bolavip.com/en/nfl">NFL</a> season. Against Indianapolis, he delivers a standout performance, completing 25 of 34 passes for 295 yards and five touchdowns while leading a dominant 48-27 victory.



Beyond the numbers, Purdy shows complete command of the offense. He reads defenses efficiently, makes quick decisions, and protects the football. Maintaining that level requires consistent protection up front, especially against a defense that aims to generate pressure and force turnovers.



Defensively, the priority is limiting Caleb Williams. Chicago’s quarterback is young, dynamic, and fearless, capable of extending plays and delivering explosive throws under pressure. Containing him means disciplined pass rush lanes, tight coverage, and forcing him to operate within structure rather than improvisation.

What happens if 49ers lose tonight against Bears on MNF in 2025 NFL Week 17?

Are Bills eliminated from 2026 NFL playoffs after losing to Eagles in Week 17?

What happens if Bears lose to 49ers on MNF tonight in Week 17 of 2025 NFL season?

What happens if 49ers lose tonight against Bears on MNF in 2025 NFL Week 17? - Bolavip US

miniaturas

The <a href="https://bolavip.com/en/topic/chicago-bears">Chicago Bears</a> face the San Francisco 49ers in Week 17 of the 2025 NFL season in a matchup that carries major playoff implications. With only one week remaining after Sunday, both teams are positioning themselves for postseason seeding and home-field advantage, making this game a critical test late in the regular season.



Both teams enter the matchup with identical 11- 4 records. San Francisco is listed as 3.5 point favorites at home, while the Bears arrive knowing that a win on Sunday Night Football could significantly improve their path through the NFC playoffs. Chicago is led offensively by quarterback Caleb Williams, while San Francisco relies on Brock Purdy under center, supported by Christian McCaffrey in the backfield.



Chicago initially believed that a Week 17 victory would be required to clinch the NFC North for the first time since 2018. However, the Green Bay Packers lost 41 to 24 against the Baltimore Ravens on Saturday Night Football, a result that officially secured the division title for the Bears before kickoff.



With the Packers’ loss, the Bears clinch the NFC North and guarantee themselves at least the No. 3 seed in the NFC playoff bracket. There remain realistic scenarios in which Chicago climbs to either the No. 1 or No. 2 seed, keeping significant stakes attached to its remaining two games.



<figure class="wp-block-gallery has-nested-images columns-default is-cropped">
<figure class="wp-block-image size-large"><figure class="image"><img loading="lazy" width="1920" height="1080" data-id="533422" src="https://ds-images.bolavip.com/news/image?src=https://images.bolavip.com/webp/en/full/BUS_20251229_BUS_553091_brock-purdy-6_a1f26c4a.webp&amp;width=1920&amp;height=1080" alt="Brock Purdy San Francisco 49ers" class="wp-image-533422"></figure><figcaption>Brock Purdy #13 of the San Francisco 49ers.</figcaption></figure>
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<h2>What happens if the Bears lose vs 49ers?</h2>



If the Chicago Bears lose to the <a href="https://bolavip.com/en/topic/san-francisco-49ers">49ers</a> in Week 17, they likely fall out of the top two seeds in the NFC, most likely settling into the No. 3 spot. While they would still be comfortably in the postseason, the loss would eliminate their control over securing a first round bye and shift their focus squarely to Week 18.


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One concern for Chicago is the matchup between its run defense and San Francisco’s rushing attack. The Bears allow over 130 rushing yards per game, ranking among the league’s weakest units in that category. The 49ers counter with Christian McCaffrey, one of the NFL’s most dynamic running backs, capable of altering games with a single explosive play.



<h2>What must happen for the Bears to win the NFC No. 1 seed?</h2>



The Bears are not in full control of the top seed. To claim the No. 1 position, Chicago must win both remaining games against the 49ers in Week 17 and the Detroit Lions in Week 18. It also needs help from the Seattle Seahawks, who must lose at least one of their final two games. A win on Sunday, however, would still move the Bears closer to locking up the No. 2 seed and maintaining momentum heading into the <a href="https://bolavip.com/en/nfl">NFL</a> postseason.

49ers HC Kyle Shanahan provides an update on Brock Purdy’s key weapon ahead of Week 17 game vs Bears

Is George Kittle playing today for 49ers vs Bears in 2025 NFL Week 17?

What happens if Bears lose to 49ers on MNF tonight in Week 17 of 2025 NFL season? - Bolavip US

The NFC is heating up with just two games remaining in the 2025 NFL regular season, and no team is ready to ease off the gas. Sunday Night Football brings an exciting showdown between the <a href="https://bolavip.com/en/topic/san-francisco-49ers">San Francisco 49ers</a> and the Chicago Bears in the Bay Area, where the home team hopes to leverage a strong offensive performance, led by Brock Purdy and key weapons such as Ricky Pearsall, to tilt the game in its favor.



Alarms went off for 49ers fans when the <a href="https://www.nfl.com/news/nfl-week-17-injury-report-player-statuses-for-all-16-games">NFL’s official site</a> listed the wide receiver as questionable for tonight’s game. However, according to Adam Schefter on X, Pearsall is likely to play for his team.



This is undoubtedly a big boost for Purdy and the 49ers’ offense, especially with questions lingering also about whether <a href="https://bolavip.com/en/nfl/is-george-kittle-playing-today-for-49ers-vs-bears-in-2025-nfl-week-17">George Kittle was playing against the Bears</a>. Ultimately, it looks like Kyle Shanahan will have, at least, one of his key pieces available for this highly significant matchup.



<h2>Pearsall’s numbers this season in the Bay</h2>



Ricky Pearsall has established himself as a reliable asset for <a href="https://bolavip.com/en/topic/brock-purdy">Brock Purdy</a> this 2025 <a href="https://bolavip.com/en/nfl">NFL</a> season, recording 31 receptions for 443 yards and a solid 14.3 average per catch. 



<figure class="wp-block-image size-full"><figure class="image"><img loading="lazy" width="1920" height="1080" src="https://ds-images.bolavip.com/news/image?src=https://images.bolavip.com/webp/en/full/BUS_20251228_BUS_552680_ricky-pearsall_0f57a8ce.webp&amp;width=1920&amp;height=1080" alt="Ricky Pearsall warms up before a game vs the Seahawks" class="wp-image-424753" sizes="(max-width: 1920px) 100vw, 1920px"></figure><figcaption>Ricky Pearsall warms up.</figcaption></figure>



Although he has yet to record a touchdown in this campaign, his ability to stretch the field and secure key first downs has made him a vital piece of the 49ers’ offensive scheme. Despite missing time due to injuries, Pearsall remains a go-to target when the team needs explosive plays to sustain momentum.


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<h2>What injury is Pearsall dealing with?</h2>



Pearsall is currently managing knee and ankle injuries sustained during the Week 15 game against the Tennessee Titans. On the very first play of that game, he suffered an ankle sprain following a controversial hip-drop tackle by Kevin Winston. 



Later in the fourth quarter, he aggravated a lingering PCL (posterior cruciate ligament) injury in his knee—the same issue that sidelined him for six games earlier this year.



<h2>Key showdown for the 49ers</h2>



Sunday Night Football presents a unique opportunity for the San Francisco 49ers to continue climbing the NFC standings. Currently, the Chicago Bears sit in second place with an 11–4 record, so a win for the 49ers would allow them to catch up, while also keeping an eye on the Eagles’ results.



The Seahawks, currently holding the No. 1 seed with a 12–3 record, could see their top spot seriously threatened if they lose to the Panthers, depending on other results. For the Niners it’s a must-win if they want to stay in the mix among the NFC contenders.

Is Ricky Pearsall playing tonight for 49ers vs Bears on SNF in Week 17 of 2025 NFL season?

Is Ricky Pearsall playing tonight for 49ers vs Bears on SNF in Week 17 of 2025 NFL season? - Bolavip US

As the San Francisco 49ers have already secured a playoff spot this season, they are preparing to face one of the most surprising teams of the regular season: The Chicago Bears. The Bears have delivered an outstanding performance so far and are keen to maintain their momentum in the final games. In their Week 17 matchup against the 49ers, they might face the challenge of playing against <a href="https://bolavip.com/en/topic/george-kittle" target="_blank" rel="noreferrer noopener">George Kittle</a>.



However, George Kittle’s participation in today’s <a href="https://bolavip.com/en/nfl" target="_blank" rel="noreferrer noopener">NFL</a> Week 17 clash between the 49ers and the Bears remains uncertain, as he has been listed as questionable on the latest injury report. He has been dealing with an ankle injury for the past few days, and according to a report from ESPN’s Adam Schefter, is “highly unlikely” that he will play.



This game means more than just a victory; the <a href="https://bolavip.com/en/topic/san-francisco-49ers" target="_blank" rel="noreferrer noopener">49ers</a>‘ position in the standings is also on the line. There are concerns about the implications of a potential loss to the Bears, which is why the fanbase is eagerly anticipating an exciting matchup today.



Meanwhile, the <a href="https://bolavip.com/en/topic/chicago-bears" target="_blank" rel="noreferrer noopener">Bears</a>‘ fanbase is similarly concerned about the repercussions of losing to the 49ers in this game. The presence of their best players is crucial, with much at stake for both franchises as they look ahead to next year’s playoffs.



<figure class="wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter"><div class="wp-block-embed__wrapper">
<div class="ck-twitter"><blockquote class="twitter-tweet" data-width="500" data-dnt="true">On the hunt.<a href="https://twitter.com/usbank?ref_src=twsrc%5Etfw">@usbank</a> | <a href="https://twitter.com/hashtag/FTTB?src=hash&amp;ref_src=twsrc%5Etfw">#FTTB</a> <a href="https://t.co/Le6NnTkJWz">pic.twitter.com/Le6NnTkJWz</a>— San Francisco 49ers (@49ers) <a href="https://twitter.com/49ers/status/2005085126439694602?ref_src=twsrc%5Etfw">December 28, 2025</a></blockquote></div><script async="" src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>
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<h2>49ers full injury report</h2>



In addition to Kittle, Ricky Pearsall is also in doubt for an appearance in today’s game against the Bears, according to the injury report. Here is the full injury report for the 49ers:


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<ul><li>Out: QB <a href="https://www.nfl.com/players/kurtis-rourke/" target="_blank" rel="noreferrer noopener">Kurtis Rourke</a> (knee), CB <a href="https://www.nfl.com/players/renardo-green/" target="_blank" rel="noreferrer noopener">Renardo Green</a> (neck)</li><li>Questionable: WR <a href="https://www.nfl.com/players/ricky-pearsall/" target="_blank" rel="noreferrer noopener">Ricky Pearsall</a> (knee/ankle), TE <a href="https://www.nfl.com/players/george-kittle/" target="_blank" rel="noreferrer noopener">George Kittle</a> (ankle)</li></ul>



<h2>Bears’ full injury report</h2>



The Bears approach this matchup with several key players listed as questionable, including Chauncey Gardner-Johnson, who is an important player that might miss today’s game against the 49ers.



Here is the full injury report for the Bears:



<ul><li>Out: WR Rome Odunze (foot), CB Nick McCloud (illness)</li><li>Questionable: RT Darnell Wright (illness), OG Luke Newman (foot), LB T.J. Edwards (glute), CB Josh Blackwell (illness), CB Nahshon Wright (hamstring/illness), S Chauncey Gardner-Johnson (knee)</li></ul>

Is George Kittle playing today for 49ers vs Bears in 2025 NFL Week 17? - Bolavip US

The <a href="https://bolavip.com/en/topic/san-francisco-49ers" target="_blank" rel="noreferrer noopener">San Francisco 49ers</a> have already clinched a spot in the playoffs, and now they have given <a href="https://bolavip.com/en/topic/brock-purdy" target="_blank" rel="noreferrer noopener">Brock Purdy</a> great news, as the club may recover a player who was expected to miss the entire season for the most important part of the year.



Injuries have hit the 49ers hard. In recent years, the club has struggled to maintain a healthy roster, but that hasn’t prevented the Niners from remaining competitive.



Earlier this year, star linebacker Fred Warner suffered a fractured and dislocated ankle. The injury was expected to sideline him for the entire season, but the club has now provided a key update ahead of the playoffs.



<h2>GM John Lynch believes Fred Warner could be ready for the playoffs</h2>



There is no doubt that the 49ers have had bad luck when it comes to injuries. Several players on both sides of the ball have dealt with health issues, but the club has managed to overcome those setbacks.



On October 12, the 49ers were dealt a major blow when Fred Warner suffered a serious ankle injury that was expected to end his season. However, the organization never completely ruled out a potential return.



General manager John Lynch has now shared a positive update on Brock Purdy’s teammate. Lynch revealed that Warner’s recovery has gone better than expected and believes the linebacker could rejoin the team for the playoffs.


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“It would be well ahead of the original timeline we were given, but Fred has the ability to move the doctors because they’re going to put objective measurements out there where, ‘Hey, if you can reach these, you can get there,’” Lynch said, via NBCSportsBayArea.com. “And Fred has continually done that. I think it’s made a lot of people kind of re-examine. ‘OK, would this be possible?’ And I think that’s a great thing. So I’m watching him. I’ve consistently said it: I won’t put anything past him.”



<h2>The 49ers can still clinch the No. 1 seed in the NFC</h2>



San Francisco has been one of the more surprising teams this season. Despite dealing with multiple injuries to key players, the 49ers hold an impressive 11–4 record and still have the opportunity to clinch the No. 1 seed in the NFC.



To do so, the 49ers would need to win out, defeating the Chicago Bears and the Seattle Seahawks—their two direct rivals in the race for the top spot in the conference.

49ers could get Brock Purdy’s star teammate back for the playoffs after expected 2025 absence

Ben Johnson sends clear warning about Kyle Shanahan as Bears prepare for 49ers showdown

George Kittle provides major injury update following 49ers’ MNF victory

49ers could get Brock Purdy’s star teammate back for the playoffs after expected 2025 absence - Bolavip US

The <a href="https://bolavip.com/en/topic/san-francisco-49ers" target="_blank" rel="noreferrer noopener">San Francisco 49ers</a> still have a chance to be the first seed in the NFC. As they prepare to face the Chicago Bears in Week 17, head coach Kyle Shanahan gave an update on one of the best teammates Brock Purdy has on the roster.



According to Cam Inman of CBS-5, <a href="https://bolavip.com/en/topic/kyle-shanahan" target="_blank" rel="noreferrer noopener">Shanahan</a> and GM John Lynch stated that George Kittle, tight end, will be a game-time decision on Sunday for the primetime showdown against the <a href="https://bolavip.com/en/topic/chicago-bears" target="_blank" rel="noreferrer noopener">Bears</a>. It will all depend on how he feels warming up.



They also provided an update on linebacker Fred Warner, who is also rehabbing from an ankle injury and could potentially make a playoff comeback. Warner has been out since Week 7.



<h2>Kittle is key for this offense</h2>



At 32 years old, <a href="https://bolavip.com/en/topic/george-kittle" target="_blank" rel="noreferrer noopener">Kittle</a> is still producing at a very high level. He has played 10 games and has 52 catches for 599 yards and seven touchdowns. He is the best weapon on the offense.



<figure class="wp-block-image size-full"><figure class="image"><img loading="lazy" width="1920" height="1080" src="https://ds-images.bolavip.com/news/image?src=https://images.bolavip.com/webp/en/full/BUS_20251226_BUS_551834_george-kittle-2_e0d3776d.webp&amp;width=1920&amp;height=1080" alt="George Kittle #85 of the San Francisco 49ers" class="wp-image-426829" sizes="(max-width: 1920px) 100vw, 1920px"></figure><figcaption>George Kittle #85 of the San Francisco 49ers</figcaption></figure>



Kittle is one of the most decorated tight ends in football. A two-time All Pro and a seven-time Pro Bowler, Kittle excels in both pass-catching and run-blocking abilities. San Francisco needs him to go on a deep playoff run.


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<h2>The 49ers control their own destiny</h2>



Much has been said about teams like the <a href="https://bolavip.com/en/topic/los-angeles-rams" target="_blank" rel="noreferrer noopener">Rams</a> or the Seahawks this season, but the 49ers actually control their destiny in the NFC West. If the Niners win out, they would not only win the division, but probably end up as the first seed in the NFC.



Kyle Shanahan has arguably put the best coaching gig of his tenured career this season, overcoming plenty of injuries. In fact, even <a href="https://bolavip.com/en/topic/brock-purdy" target="_blank" rel="noreferrer noopener">Brock Purdy</a> missed plenty of time, and Shanahan still found ways to win. If the 49ers end up as the first seed in the NFC, this could become one of the best stories in recent years.

49ers HC Kyle Shanahan provides an update on Brock Purdy's key weapon ahead of Week 17 game vs Bears - Bolavip US

The <a href="https://bolavip.com/en/topic/chicago-bears">Chicago Bears</a> head west this week for a high-stakes Week 17 showdown against the San Francisco 49ers. Ahead of the game at Levi’s Stadium, Bears head coach Ben Johnson spoke candidly about the task his defense faces and the influence of Kyle Shanahan, whose offense continues to test even the league’s best-prepared units.



Johnson did not hesitate to elevate <a href="https://bolavip.com/en/topic/kyle-shanahan">Shanahan</a> into the highest tier of play-callers in the NFL. “Kyle Shanahan is one of the best, if not the best in the business in terms of calling plays at a high level for as long as he has,” Johnson said, emphasizing the sustained excellence behind San Francisco’s system.



“You always like to turn on that <a href="https://bolavip.com/en/topic/san-francisco-49ers">San Francisco </a>tape each week, whether you’re playing them or not, just to look at some of the stuff that they’re doing,” Johnson explained. He also noted how the offense has evolved, “it’s changed… they might be a more dangerous passing offense right now.” The numbers back that up, with San Francisco averaging 26.1 points per game (9th in the NFL), while riding a five-game winning streak and remaining unbeaten at home since Week 10.



<h2>When strengths collide at Levi’s Stadium</h2>



The matchup places the Bears’ defense against one of the league’s most efficient offenses at a critical point in the season. Both teams enter Week 17 at 11–4, making the contest as much a measuring stick as it is a potential playoff preview. Recent history adds another layer, with the 49ers holding a 38–13 win over Chicago in their most recent meeting last December in San Francisco.



<div class="ck-twitter"><blockquote class="twitter-tweet" data-media-max-width="560">Bears HC Ben Johnson on the 49ers offense: “Kyle Shanahan is one of the best, if not the best in the business in terms of calling plays at a high level for as long as he has… You always like to turn on that San Francisco tape each week, whether you’re playing them or not just… <a href="https://t.co/LI1aKhviyU">pic.twitter.com/LI1aKhviyU</a>— Coach Yac 🗣 (@Coach_Yac) <a href="https://twitter.com/Coach_Yac/status/2004386213872967741?ref_src=twsrc%5Etfw">December 26, 2025</a></blockquote></div> 



Chicago’s defense has been solid but tested, allowing 23.6 points per game (19th in the NFL) and 5.9 yards per play, while surrendering 6.7 yards per pass attempt and 5.0 yards per rush. The Bears are 5–3 on the road, though their most recent away game ended in a 28–21 loss to the Packers, a result that highlighted some of the challenges they’ll need to clean up against Shanahan’s offense.


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At the center of the Bears’ defensive effort is Tremaine Edmunds, who leads the unit with 95 combined tackles and has added three quarterback hits. Chicago will likely lean on Edmunds’ range and communication to counter an offense designed to stress defenses horizontally and vertically.

Ben Johnson sends clear warning about Kyle Shanahan as Bears prepare for 49ers showdown - Bolavip US

The playoffs are now a reality for the <a href="https://bolavip.com/en/topic/san-francisco-49ers">San Francisco 49ers</a>, and their Monday Night Football win over the Colts opened the door for three other teams to clinch a postseason berth. George Kittle was one of the night’s standout performers, though he was unable to finish the game at full strength.



Midway through the second quarter of the game, the TE suffered a scare when one of his ankles appeared to get caught in the turf while running a route. Defensive coverage and the artificial surface were among the factors that may have contributed to the setback.



“My concern level? I don’t think it’s a high-ankle sprain, so we’ll take it one day at a time and go from there,” <a href="https://bolavip.com/en/topic/george-kittle">Kittle</a> said during his press conference. “It happened in the second quarter. I feel like I got hip dropped, ankle got stuck in the grass or the turf, the cork turf, really weird field. 



“Tried to tape it up, went in in the third quarter, really got worse from there. If I can’t run very fast or plant I think it’s better to have other tight ends in there making plays.”



<div class="ck-twitter"><blockquote class="twitter-tweet" data-media-max-width="560">George Kittle – Aggravated a left ankle sprain here while trying to cut. Pretty sure he injured it earlier in the game and has been trying to play through it. Feeling it out on the sideline now but deemed Questionable <a href="https://t.co/k7LfpqNHdY">pic.twitter.com/k7LfpqNHdY</a>— Jeff Mueller, PT, DPT (@jmthrivept) <a href="https://twitter.com/jmthrivept/status/2003309375637889321?ref_src=twsrc%5Etfw">December 23, 2025</a></blockquote></div> 



<h2>George Kittle’s season in the Bay</h2>



George Kittle continues to be a vital asset for the San Francisco 49ers’ offense this season, showcasing his elite playmaking ability and reliability. With 52 receptions for 599 receiving yards, he has consistently moved the chains while maintaining a solid average of 11.5 yards per catch. 


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Furthermore, his 7 touchdowns highlight his efficiency as a premier red-zone threat, proving once again why he remains one of the most dominant tight ends in the league.



<h2>The race for the NFC’s No. 1 seed</h2>



The San Francisco 49ers control their own destiny in a high-stakes race for the NFC West and the conference’s top seed. Currently battling the Seahawks, Rams, Eagles and Bears for positioning, San Francisco will look to capitalize on its final two games at Levi’s Stadium. 



By hosting both the Bears and the Seahawks at home, the 49ers have a golden opportunity to leapfrog their rivals and secure home-field advantage for the postseason.

George Kittle provides major injury update following 49ers’ MNF victory - Bolavip US

The <a href="https://bolavip.com/en/topic/indianapolis-colts">Indianapolis Colts</a> enter Week 16 with an 8-6 record, facing a highly stressful Monday Night Football matchup against the San Francisco 49ers. A loss could effectively end their playoff hopes, as they currently hold just a 5 percent chance of reaching the postseason.



If the Colts lose to the <a href="https://bolavip.com/en/topic/san-francisco-49ers">49ers</a>, their playoff probability would drop to 3% percent, making it nearly impossible to compete for a Wild Card spot or any other path to the playoffs. That scenario becomes even more concerning given that Indianapolis has not won a game since Week 10.



Philip Rivers represents the Colts’ biggest source of hope. The team needs to avoid a loss against the 49ers with a quarterback who defeated them four times during his years with the Chargers. Last week against the Seahawks, Rivers threw for 120 passing yards with one touchdown and one interception.



<h2>AFC South standings and the scenario that puts the Colts in the playoffs</h2>



The AFC South is firmly controlled by the Jacksonville Jaguars at 11-4, with the Houston Texans in second place at 10-5 and the Colts sitting third at 8-6. All of this comes before the matchup against the 49ers, a game that could significantly improve Indianapolis’ playoff chances if the Colts manage to win, as explained by Colts writer and <a href="https://bolavip.com/en/nfl">NFL</a> Draft analyst Destin Adams on X.



<div class="ck-twitter"><blockquote class="twitter-tweet" data-media-max-width="560">tonight. <a href="https://t.co/imXSUf530I">pic.twitter.com/imXSUf530I</a>— Indianapolis Colts (@Colts) <a href="https://twitter.com/Colts/status/2003119071706087833?ref_src=twsrc%5Etfw">December 22, 2025</a></blockquote></div>



“If the Colts lose this week and win out, their chances are 18 percent. If they win out, they are at 86 percent. It’s not impossible to make it with just two wins down the stretch, but winning this week improves their odds tremendously,” Adams wrote on X (@thedestinadams).


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In simple terms, the Colts not only cannot afford to lose to the 49ers, but they must also beat the Jaguars and Texans, both division rivals. However, Indianapolis is 2-2 against AFC South teams this season and already lost to both the Jaguars and Texans three weeks ago.

What happens if Colts lose to 49ers on MNF tonight in Week 16 of 2025 NFL season?

What happens if Colts lose to 49ers on MNF tonight in Week 16 of 2025 NFL season? - Bolavip US

The <a href="https://bolavip.com/en/topic/san-francisco-49ers">San Francisco 49ers</a> enter Monday Night Football with a 10-4 record and a strong winning streak, fully prepared to face the Indianapolis Colts, who could pose a real threat in Week 16. Even so, a loss would not necessarily be disastrous for San Francisco.



If the 49ers were to lose to the <a href="https://bolavip.com/en/topic/indianapolis-colts">Colts</a>, it would not mark the end of their postseason path. They have already secured a playoff spot after clinching a Wild Card berth thanks to the Lions’ loss to the Steelers on Sunday. Still, avoiding a loss remains important as they continue to chase the top spot in the NFC West.



Last week, Brock Purdy threw for 295 passing yards and three touchdowns in a 37-24 home victory. That win marked the team’s fourth since Week 11. The streak includes two road wins for the 49ers, a 41-22 victory over the Cardinals and a 20-9 win against the Cleveland Browns.



<h2>Standings and the path to winning the NFC West</h2>



Before the 49ers face the Colts in Week 16, the NFC West is led by the Seattle Seahawks with a 12-3 record. The Los Angeles Rams sit in second place at 11-4, while San Francisco is currently third. The 49ers not only hold a 10-4 overall record, but they also lead the division in wins against NFC West opponents with a 4-1 mark.



<div class="ck-twitter"><blockquote class="twitter-tweet" data-media-max-width="560">"If the Rams win out they win the NFC West &amp; they&apos;re the 1 seed … If Seattle wins and they win out, they&apos;re the NFC West champs &amp; the 1 seed." "If Seattle beats the Rams but the 49ers win out, (which means the 49ers beat Seattle in week 18) then the 49ers are not only the NFC… <a href="https://t.co/LlWHP8yp2y">pic.twitter.com/LlWHP8yp2y</a>— Fitz &amp; Whit (@fitzandwhit) <a href="https://twitter.com/fitzandwhit/status/2001683960531661215?ref_src=twsrc%5Etfw">December 18, 2025</a></blockquote></div> 



The NFC West race is one of the most complicated scenarios in the league, with several possible outcomes still in play. The 49ers remain alive in the division race and could still win the NFC West and secure the top seed, as outlined on Fitz &amp; Witz: “If the Rams win out, they win the NFC West and they’re the No. 1 seed. If Seattle wins and they win out, they’re the NFC West champs and the No. 1 seed,” the show explained.


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“If Seattle beats the Rams but the 49ers win out, which would mean the 49ers beat Seattle in Week 18, then the 49ers are not only the NFC West champions but also the No. 1 seed in the NFC. That seems crazy to me.”



<h2>More than 20 years without beating the Colts</h2>



The 49ers have gone more than 20 years without defeating the Colts. Their last win in the series came in 2001, meaning San Francisco has not beaten Indianapolis in 24 years. The most recent matchup took place in San Francisco in 2021, when the home team lost 30-18. Purdy was not the quarterback at the time, as Jimmy Garoppolo started that game and finished with one touchdown and two interceptions.



The situation for the Colts is difficult. They will play at home with Philip Rivers at quarterback, and the team is currently in crisis. Indianapolis needs to avoid a loss even more urgently than San Francisco needs a win. The Colts have not won a game since Week 10, when they defeated the Falcons in Germany.



<div class="ck-twitter"><blockquote class="twitter-tweet" data-media-max-width="560">Kyle Shanahan explains why 44-year-old Philip Rivers is better than most 22-year-old quarterbacks. <a href="https://t.co/8LNPm2oNJp">pic.twitter.com/8LNPm2oNJp</a>— Grant Cohn (@grantcohn) <a href="https://twitter.com/grantcohn/status/2001750901359563069?ref_src=twsrc%5Etfw">December 18, 2025</a></blockquote></div> 



The 49ers’ offense could have a favorable matchup against the Colts. San Francisco is averaging 24.6 points per game, ranking 10th in the <a href="https://bolavip.com/en/nfl">NFL</a> this season. Just as important, the defense is allowing only 20.9 points per game. The Colts have failed to score 20 points in each of their last three games.

What happens if 49ers lose today against Colts on MNF in 2025 NFL Week 16?

What happens if 49ers lose today against Colts on MNF in 2025 NFL Week 16? - Bolavip US

The <a href="https://bolavip.com/en/topic/san-francisco-49ers" target="_blank" rel="noreferrer noopener">San Francisco 49ers</a> are playing on Monday Night Football in Week 16 against the Indianapolis Colts. Brock Purdy is getting updates on one of his key weapons ahead of this crucial matchup.



According to Matt Barrows of The Athletic, wide receiver Ricky Pearsall didn’t practice on Thursday due knee and ankle injuries. However, given that the game is on Monday, <a href="https://bolavip.com/en/topic/kyle-shanahan" target="_blank" rel="noreferrer noopener">Shanahan</a> stays positive.



Per Barrows, Shanahan said, “He’s doing a lot better today than he was on Monday,” so there is hope that Brock Purdy will have one of his best weapons available again. After all, the <a href="https://bolavip.com/en/topic/indianapolis-colts" target="_blank" rel="noreferrer noopener">Colts</a> might be on a bad streak, but they are a tough team to face, especially with extra days of preparation.



<h2>Pearsall’s season has been filled with injuries</h2>



Pearsall has been able to play on eight games this season, and he has 31 receptions for 443 yards. This means he already surpassed his total tally from last season, despite dealing with lingering injuries throughout the campaign, especially with some knee injuries. 



<figure class="wp-block-image size-full"><figure class="image"><img loading="lazy" width="1920" height="1080" src="https://ds-images.bolavip.com/news/image?src=https://images.bolavip.com/webp/en/full/BUS_20251218_BUS_547961_ricky-pearsall_6e05ab6e.webp&amp;width=1920&amp;height=1080" alt="Ricky Pearsall" class="wp-image-522780"></figure><figcaption>Ricky Pearsall #1 of the San Francisco 49ers.</figcaption></figure>



Still, he’s already missed a quarter of the games played. If Pearsall is able to log another appearance, he will surely be one of the most seeked weapons by <a href="https://bolavip.com/en/topic/brock-purdy" target="_blank" rel="noreferrer noopener">Brock Purdy</a>. Kyle Shanahan loves to establish the run game, and then exploit the play-action where Purdy thrives.


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<h2>The 49ers could keep their overachieving season going</h2>



If there is one team that has really suffered the consequences of big injuries, it’s the 49ers. Since the beginning of the season, they’ve seen star after star getting injured. Still, the 49ers are 10-4 and in absolute playoff race.



The end of the schedule isn’t easy either. The Indianapolis Colts await. Then, the Chicago Bears and Seattle Seahawks are next. All three teams hold a winning record and with that, it’s a tough stretch to end the season and go to the <a href="https://bolavip.com/en/nfl" target="_blank" rel="noreferrer noopener">NFL</a> Playoffs.

Brock Purdy gets update on key weapon ahead of 49ers Week 16 MNF game vs Colts

Brock Purdy gets update on key weapon ahead of 49ers Week 16 MNF game vs Colts - Bolavip US

The <a href="https://bolavip.com/en/topic/san-francisco-49ers" target="_blank" rel="noreferrer noopener">San Francisco 49ers</a> are deep into a playoff push, so when star running back Christian McCaffrey appeared on the team’s injury report, alarms went off. Will he play today in Week 15’s matchup against the Tennessee Titans?



According to Adam Schefter of ESPN, McCaffrey is officially active against the <a href="https://bolavip.com/en/topic/tennessee-titans" target="_blank" rel="noreferrer noopener">Titans</a>. McCaffrey’s late add to the injury report was due to a back issue, but it seems it won’t deter him from playing.



<a href="https://bolavip.com/en/topic/christian-mccaffrey" target="_blank" rel="noreferrer noopener">McCaffrey</a> is crucial for this team. The whole offense moves around him. McCaffrey has 849 rushing yards, 806 receiving yards and a total of 13 touchdowns this season. He is as deadly as a weapon can be in the NFL.



<h2>If McCaffrey is limited, who’s next?</h2>



If McCaffrey is limited or suffers another setback, Brian Robinson Jr. is the next man up on the depth chart. Robinson has a similar skillset to McCaffrey in the fact that he is also a dual-threat running back, albeit much less effective to what CMC produces. Robinson is a very good back, but McCaffrey is simply elite.



<figure class="wp-block-image size-full"><figure class="image"><img loading="lazy" width="1920" height="1080" src="https://ds-images.bolavip.com/news/image?src=https://images.bolavip.com/webp/en/full/BUS_20251214_BUS_545160_brian-robinson_153e3ece.webp&amp;width=1920&amp;height=1080" alt="Brian Robinson Jr. #3 of the San Francisco 49ers" class="wp-image-545166"></figure><figcaption>Brian Robinson Jr. #3 of the San Francisco 49ers</figcaption></figure>



Robinson arrived this season to the team after being on the Commanders. He has played a secondary role to McCaffrey, but when called upon, he has delivered. Robinson has 328 yards and two touchdowns this year.


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<h2>Shanahan loves himself a good running game</h2>



Famous for making pretty much anyone a decent-to-good back, 49ers head coach <a href="https://bolavip.com/en/topic/kyle-shanahan" target="_blank" rel="noreferrer noopener">Kyle Shanahan</a> knows a good running game is key to win games and control the clock. Hence, it’s in his best interest to always have a solid running game.



Statistically, the 49ers have the 25th-ranked rushing offense, but McCaffrey is able to provide enough damage anyway. Against the Titans, it’s key for the Niners to make long drives and rely on McCaffrey’s production to not even sweat a must-win game.

Is Christian McCaffrey playing today for 49ers vs Titans in 2025 NFL Week 15?

Is Christian McCaffrey playing today for 49ers vs Titans in 2025 NFL Week 15? - Bolavip US

<a href="https://bolavip.com/en/topic/kurt-warner">Kurt Warner</a> raised eyebrows when asked a hypothetical that has suddenly gained traction: If Joe Burrow wanted out of Cincinnati, should the 49ers pursue him? Warner didn’t dodge the question, acknowledging both the difficulty and the weight of it. “That’s a tough question,” he said.



Despite his admiration for Brock Purdy, Warner made it clear he views Burrow on another tier. “You know I love <a href="https://bolavip.com/en/topic/brock-purdy">Brock Purdy</a> and I think Brock’s really good, but I also do believe Joe is better than Brock is and brings more to the table,” Warner explained, highlighting Burrow’s rare combination of talent and command.



Warner added that Burrow wouldn’t just be an upgrade in <a href="https://bolavip.com/en/topic/san-francisco-49ers">San Francisco</a>, but almost anywhere. “If that were the case you’d probably have 28 teams in the league that would say Joe Burrow would be an upgrade at the quarterback spot. That’s not a knock on any of these other guys. It’s just Joe is one of the special ones.”



<h2>Who has been better recently, Purdy or Burrow?</h2>



Brock Purdy played in the 2024 Super Bowl, where the 49ers unfortunately lost. He now joins Joe Burrow on the list of quarterbacks who debut in a major game like that but often struggle to return to the sport’s most important stage, though the future will tell if either can play another Super Bowl.



<div class="ck-twitter"><blockquote class="twitter-tweet" data-media-max-width="560">Kurt Warner was asked if Joe Burrow wants out of Cincinnati, should the 49ers trade for him: “That’s a tough question. You know I love Brock Purdy and I think Brock’s really good, but I also do believe Joe is better than Brock is and brings more to the table. If that were the… <a href="https://t.co/BLkUZPvHRt">pic.twitter.com/BLkUZPvHRt</a>— Coach Yac 🗣 (@Coach_Yac) <a href="https://twitter.com/Coach_Yac/status/1999272452812062947?ref_src=twsrc%5Etfw">December 12, 2025</a></blockquote></div>



In terms of stats, last season was truly excellent for Burrow, who accumulated 4,918 yards and 43 touchdowns with only nine interceptions. However, all of that was not enough to reach the playoffs. On the other hand, despite the injuries to his teammates, Purdy managed to accumulate 3,864 passing yards and 20 touchdowns but threw 12 interceptions.


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Both Burrow and Purdy have played in two postseasons with their respective teams. The Bengals quarterback has a bit more experience than the 49ers quarterback, as he has been playing as a starter virtually since 2020 and surpasses Purdy in all major passing categories.

Kurt Warner reveals which star QB he believes would be an upgrade over Brock Purdy

Kurt Warner reveals which star QB he believes would be an upgrade over Brock Purdy - Bolavip US

The San Francisco 49ers are currently having an impressive campaign in the NFL, remaining among the contenders in their division with just a few games left in the regular season. Even more remarkable is that <a href="https://bolavip.com/en/topic/kyle-shanahan">Kyle Shanahan</a> has managed to keep his offense performing without Brandon Aiyuk, who has yet to make his season debut due to injury.



The wide receiver is still rehabbing after tearing the ACL, MCL, and meniscus in his right knee—a severe injury he suffered in October of last year. Could <a href="https://bolavip.com/en/topic/brandon-aiyuk">Aiyuk</a> return to the field alongside his teammates this season? Shanahan is optimistic.



“Oh, I’m definitely still hopeful,” the head coach said on KNBR, via David Bonilla of 49erswebzone.com. “I’m not counting on it, but I’m definitely still hoping that can happen.”



So far this season, the offense, led in part by Brock Purdy and Mac Jones, has relied on its top receivers, Ricky Pearsall and Jauan Jennings. It remains to be seen whether Aiyuk will get a chance to see any snaps this year.



<figure class="wp-block-image size-full"><figure class="image"><img loading="lazy" width="1920" height="1080" src="https://ds-images.bolavip.com/news/image?src=https://images.bolavip.com/webp/en/full/BUS_20251203_BUS_538303_kyle-shanahan-4_866ab020.webp&amp;width=1920&amp;height=1080" alt="Kyle Shanahan" class="wp-image-538341"></figure><figcaption>Head coach Kyle Shanahan of the San Francisco 49ers.</figcaption></figure>



<h2>Lynch comments on Aiyuk’s situation</h2>



Aiyuk has yet to see action this <a href="https://bolavip.com/en/nfl">NFL</a> season, and the opening of the 21-day window still seems far off. In fact, they’ll have to wait at least until after the team’s bye week, though Bay Area GM John Lynch doesn’t believe they’ll get to see the receiver on the field this season.


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“Realistic, I’m not sure,” Lynch said on KNBR. “Hopeful, yeah. I think that’s where I’d leave that . . . We’re a better football team when Brandon’s out there, but that’s probably what it is, hope right now.”



Additionally, the <a href="https://bolavip.com/en/topic/san-francisco-49ers">49ers</a>’ General Manager made his stance clear regarding the receiver’s contract negotiations, which could have, in some way, affected the relationship between the two parties.



“I don’t necessarily know that the reporting was an inflection point, but I think, the entire time, it hadn’t been great,” he said. “And so, you do your best to rectify those things, and then, everyone’s got to be professionals and conduct themselves in that manner.”

49ers HC Kyle Shanahan makes big admission about Brandon Aiyuk’s potential return this NFL season

49ers HC Kyle Shanahan makes big admission about Brandon Aiyuk’s potential return this NFL season - Bolavip US

The <a href="https://bolavip.com/en/topic/san-francisco-49ers" target="_blank" rel="noreferrer noopener">San Francisco 49ers</a> won a tough visit against the Cleveland Browns. The game got chirpy and then, a Shedeur Sanders teammate had something to say regarding one of the rival players.



A week ago, 49ers’ Jauan Jennings suffered a low blow. Well, for <a href="https://bolavip.com/en/topic/cleveland-browns" target="_blank" rel="noreferrer noopener">Browns</a> defensive tackle Shelby Harris, he deserved it: “He’s a h–, and I want that known. Like I see why he got punched in the nuts, because he said some things that you should not say to another man, ever. But, like, I don’t respect it because you say that, then run behind your O-line. That’s some real soft s—, and I want that known. I see exactly why they punched him in the nuts. I’m surprised nobody’s punched him in the jaw yet.“



<a href="https://bolavip.com/en/topic/myles-garrett" target="_blank" rel="noreferrer noopener">Myles Garrett</a> also spoke on the matter, saying, “I can’t speak for how he was raised, but if you have nothing good to say, don’t say something to somebody. So, he had a lot to say that was demeaning and disparaging towards some of our players. And I was just trying to separate everybody. And I tried to go up and ask for what the problem was, and then he started coming at me and, I mean, some guys just roll like that.”



<h2>Jennings hasn’t spoken on any incident</h2>



After last week’s low blow, Jennings retaliated with a right slap and he was fined. After the Browns game, Jennings wasn’t spotted in the postgame locker room. Which makes it all but more suspicious.



<figure class="wp-block-image size-full"><figure class="image"><img loading="lazy" width="1920" height="1080" src="https://ds-images.bolavip.com/news/image?src=https://images.bolavip.com/webp/en/full/BUS_20251201_BUS_537355_jauan-jennings_a1fea075.webp&amp;width=1920&amp;height=1080" alt="Jauan Jennings #15 of the San Francisco 49ers" class="wp-image-507540" sizes="(max-width: 1920px) 100vw, 1920px"></figure><figcaption>Jauan Jennings #15 of the San Francisco 49ers</figcaption></figure>



Jennings is a very good receiver, and actually had four catches for 39 yards and one touchdown. However, if he continues to make enemies, he could expose himself to being targeted by opposing defenses.


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<h2>The 49ers can’t afford to lose another weapon</h2>



San Francisco is very injured right now, so the 49ers can’t afford that someone hits Jennings with bad intentions and sidelines him. If Jennings gets injured, the 49ers don’t have any other receiver with his skills.



It’s not like quarterback Brock Purdy is playing lights out right now, so he needs all the help he can get. In fact, <a href="https://bolavip.com/en/topic/shedeur-sanders" target="_blank" rel="noreferrer noopener">Shedeur Sanders</a> might have outplayed him on Sunday. Purdy is constantly saved by Jennings’ huge catch ratio and safe hands. It might not seem like it, but Jennings is more important to this team than what meets the eye.

Shedeur Sanders teammate makes strong claim against 49ers player after Browns’ loss in Week 13

Shedeur Sanders teammate makes strong claim against 49ers player after Browns' loss in Week 13 - Bolavip US

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