NFL

New Orleans Saints vs Buffalo Bills: Predictions, odds, and how to watch 2021 NFL season | Thanksgiving Day Game | Thursday Night Football

The New Orleans Saints host the Buffalo Bills tonight in the final game ofThanksgiving Day in Week 12 of the 2021 NFL regular season. Here, check out the preview, predictions, odds, and how to watch this Thursday Night Football matchup in the US.

Trevor Siemian of the New Orleans Saints (left) and Josh Allen of Buffalo Bills.
© Tim Nwachukwu/Michael Reaves/Getty ImagesTrevor Siemian of the New Orleans Saints (left) and Josh Allen of Buffalo Bills.

The New Orleans Saints and the Buffalo Bills wrap up Thanksgiving Daytonight with an exciting Thursday Night Football showdown in Week 12 of the 2021 NFL Regular Season. Here, you will find everything you need to know, such as the preview, predictions, and odds. To watch the game, tune in to fuboTV (7-day free trial) or Paramount+ (free trial).

Advertisement

The Saints return home aiming to end a three-game losing streak that has seen their record go from 5-2 to 5-5, thereforesitting second in the NFCSouth behind the Tampa Bay Buccaneers.

On the other hand, the Bills will make the trip to New Orleans also hoping to bounce back from a defeat last time out. Buffalo’s latest loss has seen them lose first place of the AFC East(6-4) to the red-hot New England Patriots (7-4).

Advertisement

New Orleans Saints vs Buffalo Bills: Match Information

Date: Thursday, November 25, 2021
Time: 8:20 PM (ET)
Location: Mercedes-Benz Superdome, New Orleans

New Orleans Saints vs Buffalo Bills: Time by State in the US

ET: 8:20 PM
CT: 7:20 PM
MT: 6:20 PM
PT: 5:20 PM

New Orleans Saints vs Buffalo Bills: Storylines

Injuries have caught up with the New Orleans Saints early in the NFL season. Alvin Kamara would remain on the sidelines, which is why all the eyes will be on Mark Ingram, who ran for 88 yards on Sunday’spainful loss against the Philadelphia Eagles.

Advertisement

Backup QB Trevor Siemianthrew for 214 yards, three touchdowns, and two interceptions. With Jameis Winston out for a long time, his team will needSiemian to build from that performance and lead them to a win this time. The next challenge won’t be easy, though.

The Buffalo Bills aim to bounce back following theirshockingloss to theIndianapolis Colts. Josh Allenthrew for 209 yards, twotouchdownsand twointerceptionsthat time. Buthe has work to do withfour TDs and five INTs in his last three games. Additionally, therush defense will also try to turn the page afterJonathan Taylormade a mess last weekend.

Advertisement

How to watch or live stream New Orleans Saints vs Buffalo Bills in the US

The Thursday Night Football game to be played between New Orleans Saints and Buffalo Bills will be broadcast in the US on fuboTV and Paramount+. Other option: NBC.

New Orleans Saints vs Buffalo Bills: Predictions and Odds

Oddsmakers have already revealed their predictions for this game. FanDuel favors the Buffalo Bills by six points, while it also believes this encounter will be full of points.

Advertisement
FanDuel
Handicap Bills -6
Game Total o/u 45

* Odds via FanDuel.

ALSO READ
Can the Dolphins still make the 2025 NFL playoffs after win vs Saints?
NFL

Can the Dolphins still make the 2025 NFL playoffs after win vs Saints?

Why is Alvin Kamara not playing today for the Saints vs Dolphins in Week 13 of 2025 NFL season?
NFL

Why is Alvin Kamara not playing today for the Saints vs Dolphins in Week 13 of 2025 NFL season?

Is Chris Olave playing today for the Saints vs Dolphins in Week 13 of 2025 NFL season?
NFL

Is Chris Olave playing today for the Saints vs Dolphins in Week 13 of 2025 NFL season?

Joe Burrow reveals he was a Saints fans growing up
NFL

Joe Burrow reveals he was a Saints fans growing up

Better Collective Logo