Manchester United will welcome Newcastle at the Old Trafford in Manchester in the fourth round of the 2021-22 Premier League season on Saturday, September 11, 2021, at 10:00 AM (ET). Here, you will find the expected lineups of both teams that will appear in Matchday 4 of the Premier League.

This will be their 53rd EPL meeting. There are no surprises here as Manchester United are the firm favorites in head-to-head clashes, having celebrated a victory on 31 occasions so far; Newcastle have grabbed a triumph just seven times to this day, and a great number of even 14 matches have ended in a draw.

Their most recent game was played on February 21, 2021, when the Red Devils smashed the Magpies with a final result of 3-1 at home at Old Trafford. It promises to be a more exciting clash as they meet for the first time in the new 2021/2022 Premier League season.

Manchester United vs Newcastle: Possible lineups for 2021-2022 Premier League Matchday 4

Cristiano Ronaldo is expected to make his second Manchester United debut on Saturday at Old Trafford. The veteran is slated to start as center-forward on Saturday. In addition, after recovering from the injury that had ruled him out of international duty, Jadon Sancho may become part of an attacking quartet with Ronaldo, Greenwood, and Bruno Fernandes.

Scott McTominay has also overcome his injury woes but he will still not be available, and Brazil international Fred has been suspended by FIFA, therefore Donny van de Beek may make a rare midfield start alongside Paul Pogba. Marcus Rashford is currently recuperating from a shoulder procedure, but Dean Henderson, Alex Telles, and Phil Jones have all returned to full training.

On the other hand, Newcastle will be without Callum Wilson, who had suffered a thigh injury in the draw with Southampton before the international break, therefore Joelinton may partner Saint-Maximin up forward. As a result of their injuries, Martin Dubravka, Jonjo Shelvey, Ryan Fraser, Karl Darlow, and Elliott Anderson will not be able to play.

However, Isaac Hayden and Paul Dummett may be available. If Hayden is healthy and fit enough, he may replace the Paraguayan international Miguel Almiron owing to the identical judgment that would keep Fred out of this encounter.

Manchester United possible starting XI:
De Gea; Wan-Bissaka, Varane, Maguire, Shaw; Van de Beek, Pogba; Greenwood, Fernandes, Sancho; Ronaldo.

Newcastle possible starting XI:
Woodman; Fernandez, Lascelles, Schar; Murphy, Willock, Longstaff, Hayden, Ritchie; Saint-Maximin, Joelinton.