Independiente Santa Fe and River Plate finally face off in Matchday 3 of the Copa Libertadores 2021 today. The game was at risk of being indefinitely postponed due to the chaotic situation in Colombia, but the CONMEBOL decided to relocate it to Paraguay, just like Atletico Nacional's duel with Argentinos Juniors. Here, take a look at the match information, storylines, predictions, odds, and even how to watch it in the US.

El Cardenal will have to face this game under difficult circumstances. They had to leave home as the country is living turbulent days and the social tension rose heavily. Besides, Harold Rivera Roa's side suffered a huge blow in the domestic league last weekend.

El Millonario, however, are not arriving at this game in the best form either. River suddenly had to leave Colombia as the game was moved and even though they began their continental campaign correctly, Marcelo Gallardo's boys have been struggling in the Argentine Copa de la Liga Profesional. Will they recover their best form in South America's greatest tournament?

Independiente Santa Fe vs River Plate: Match Information

Date: Thursday, May 6, 2021
Time: 8 PM (ET)
Location: La Nueva Olla, Asunción, Paraguay

Independiente Santa Fe vs River Plate: Time by State in the US

ET: 8 PM
CT: 7 PM
MT: 6 PM
PT: 5 PM

Independiente Santa Fe vs River Plate: Storylines

Independiente Santa Fe are under pressure to overcome an extremely difficult situation. Not only they would need to recover after a weak start to the continental contest's group stage, but El Leon were upset in the domestic tournament as well.

Rivera Roa's team was knocked out in the Apertura quarterfinals by Junior. Besides, the club is also shaken by all the riots and conflicts going on in its country. After losing against Fluminense last week, Santa Fe will seek recovery against arguably the strongest side in Group F. 

River Plate earned a much-needed win over Junior last week at Estadio Monumental, but while they began their Copa Libertadores 2021 journey decently, El Millonario left fans concerned in the last rounds of the local competition. Gallardo's team was beaten in the last two rounds, and it is barely inside the top four of Group A with one game left. Winning this upcoming clash may give them a boost to recover in the Argentine League and to strengthen themselves in their pursuit of South American glory.

Independiente Santa Fe vs River Plate: Copa Libertadores 2021 Standings

After Matchday Two, River Plate are currently tied with Fluminense as both have four points each. On the other hand, Independiente Santa Fe only hold one point, just like Junior.

Independiente Santa Fe vs River Plate: Copa Libertadores 2021 Top Scorers

With one goal each, Daniel Giraldo and Kelvin Osorio are Independiente Santa Fe's top scorers so far. Meanwhile, River Plate's leading goalscorers after two rounds are Gonzalo Montiel, Julián Alvarez, and Héctor Martínez, who all have been on target once.

How to watch or live stream Independiente Santa Fe vs River Plate in the US

The Copa Libertadores 2021 game for Matchday 3 of Group F to be played between Independiente Santa Fe and River Plate will be broadcast in the US by Fanatiz, beIN SPORTS en Español, beIN SPORTS, and beIN SPORTS CONNECT.

Independiente Santa Fe vs River Plate: Predictions and Odds

Oddsmakers in the US haven't unveiled their predictions yet. However, according to Caliente, River Plate are expected to claim the three points as they were given odds of -138, while Independiente Santa Fe have +350. Meanwhile, a tie would result in a +280 payout.

Independiente Santa Fe +350
Tie +280
River Plate -138

* Odds via Caliente.