Los Angeles Chargers and San Francisco 49ers meet in Week 2 of the NFL Preseason 2021. This game will be held at Levi's Stadium in Santa Clara today at 4:30 PM (PT). Here is all the related information about this NFL Preseason game including the preview, storylines, predictions, odds and how to watch in the US.

The home team won the first week against city rival Los Angeles Rams 13-6. That game was even in the first half with six points for each team. But in the third quarter the Chargers scored 7 points to win and play the rest of the game in defensive mode.

The San Francisco 49ers lost the first game of the 2021 NFL Preseason to the Kansas City Chiefs 19-16. The first quarter of that game was tight from the first minute, the Chiefs won the quarter 7-6. In the last quarter the history was the same for the Chiefs with a score of 9-7.

Los Angeles Chargers vs San Francisco 49ers: Match Information

Date: Sunday, August 22, 2021.
Time: 4:30 PM (PT)
Location: Levi's Stadium, Santa Clara, California.

Los Angeles Chargers vs San Francisco 49ers: Times by State in the US

ET: 7:30 PM
CT: 6:30 PM
MT: 5:30 PM
PT: 4:30 PM

Los Angeles Chargers vs San Francisco 49ers: Storylines

Last season for the Chargers was negative at 7-9 overall. The AFC West was completely dominated by the Kansas City Chiefs. The worst team in that division were the Broncos. The last time they won the division was in 2009.

The San Francisco 49ers are planning to use some players from the roster to test few plays during this game. Next week, the last of theNFL Preseason, will be the last chance for the rookies and the veterans will jump into action to play the last game before the regular season.

The Chargers are considering using Eason Stick against the 49ers as a starting quarterback, but this is not confirmed yet. On the 49ers' side, they will use Trey Lance again after a good run against the Chiefs with 128 passing yards and a touchdown.

How To Watch Or Stream Live Free Los Angeles Chargers vs San Francisco 49ers in the U.S.

The NFL Preseason is available on Television, Radio and Live Streaming on the Internet, this and other games will be broadcast in the United States by: FuboTV, 49ers App, NFL Game Pass. Don't forget to download the app to watch the game on your smartphone.

Los Angeles Chargers vs San Francisco 49ers: Predictions And Odds

Los Angeles Chargers are not favorites at home, they are underdogs with +5.5 ATS and +190 moneyline at FanDuel. The Chargers don't have a good record against the 49ers, the record is negative with 22 wins and 26 losses. The 49ers are favorites for this game with -5.5 points to cover and -230 moneyline odds. The totals is fixed at 34 points.

Los Angeles Chargers +5.5 / +190
Totals O/U 34
San Francisco 49ers -5.5 / -230

* Odds via FanDuel