Oh, it's Fantasy Football season! That means that some friendships are about to end, people are going to make up excuses, and chances are that the guy who doesn't have a single clue of football ends up winning your league.

To prevent that, we're going to talk about this week's top waiver wire pickups, those guys that are somehow still free agents and that most casual fans slept on. That, my friend, is the key to winning in this business.

We've got plenty of interesting matchups on Sunday. Unfortunately, we can't talk about every single team. So, without any further ado, let's take a look at the top 4 players you should pick up right now.

2021 NFL Fantasy: Waiver Wire Pickups For Week 2

QB: Jameis Winston - New Orleans Saints

Jameis Winston. (Getty)

Jameis Winston. (Getty)

Ok, maybe it's time to start buying into the Jameis Winston hype? He was lights out against the Green Bay Packers' tough defense and we all know he can put up numbers in bunches, even if that doesn't always translate into wins.

The New Orleans Saints will face a revamped defense in the Carolina Panthers and they don't exactly have a lot of weapons, but an inspired Winston is capable of moving the chains - for better or worse - in a divisional matchup.

WR: Christian Kirk - Arizona Cardinals

Christian Kirk. (Getty)

Christian Kirk. (Getty)

The Arizona Cardinals' offense was firing at all cylinders during Week 1, and we don't expect the so-called new-look Minnesota Vikings' defense to stop them whatsoever, especially in their first home game of the season.

While DeAndre Hopkins may steal most of the headlines, Christian Kirk and Kyler Murray have developed plenty of rapport. He made the most of his 5 catches last week with 2 touchdowns, so pick him up as soon as you can.

RB: Elijah Mitchell - San Francisco 49ers

Elijah Mitchell. (Getty)

Elijah Mitchell. (Getty)

If somehow, someway Elijah Mitchell is still up for grabs on your Fantasy league, then stop reading this and go grab him ASAP. He's going to be the most picked-up player this week and for very, very good reasons.

The San Francisco 49ers just lost Raheem Mostert for the season and Elijah Mitchell ran for 100 yards in 19 carries and looks like he's far ahead of JaMycal Hasty in Harbaugh's depth chart. 

TE: Jared Cook - Los Angeles Chargers

Jared Cook. (Getty)

Jared Cook. (Getty)

Not many people trusted the veteran tight end to make an impact with the Los Angeles Chargers but guess what? Jared Cook will be a valuable asset throughout the whole season. He's one of their most reliable pass-catchers and a perennial threat in the red zone.

Justin Herbert is THAT dude. He was able to move the chains against one of the league's fiercest defenses, so just imagine what he'll do to the Dallas Cowboys in Week 2. Spoiler alert: Look what Gronk did to them in the season opener.