NFL

Why is Kyler Murray not playing today for Cardinals vs Colts in Week 6 of 2025 NFL season?

The Arizona Cardinals are eager to rebound following their challenging defeat to the Tennessee Titans. However, fans already know star quarterback Kyler Murray will not take the field against the Indianapolis Colts in their Week 6 matchup.

Kyler Murray #1 of the Arizona Cardinals in action.
© Norm Hall/Getty ImagesKyler Murray #1 of the Arizona Cardinals in action.

Kyler Murray and the Arizona Cardinals are at a critical juncture, needing victories in the upcoming weeks to keep pace with rival teams and secure a playoff berth this season. Following a disappointing performance against the Tennessee Titans in Week 5, today’s game against the Indianapolis Colts represents a crucial opportunity for the Cardinals to recalibrate and regain momentum.

It’s shaping up to be a formidable contest. The Colts have surged to a strong 4-1 record in the NFL regular season, while the Cardinals have managed two wins alongside three losses. With this context, Cardinals fans are hopeful their roster will remain resilient, providing the foundation for crucial victories in the coming weeks.

The Arizona camp faced significant criticism regarding their execution against the Titans. Fumbles and costly errors marred what was an otherwise promising outing, ultimately resulting in a narrow one-point loss that the Cardinals‘ faithful endured in Week 5.

Advertisement

While such struggles continue for the Cardinals, the Colts narrative is starkly different, co-leading the AFC South standings with the Jacksonville Jaguars. The Week 6 contest serves as a pivotal occasion for the Colts to sustain their impressive run and reinforce their Super Bowl credentials.

Tweet placeholder
Advertisement

Why is Murray not playing today for Cardinals vs Colts?

Kyler Murray will not take the field today for the Arizona Cardinals vs Indianapolis Colts due to a confirmed injury. As first reported by ESPN’s Adam Schefter, and then confirmed by the team, Murray will continue to recover from his injury, with his return date remaining uncertain for now.

Stephen A. Smith sends blunt message about Kyler Murray’s future with Cardinals

see also

In Murray’s absence, the Cardinals face the significant challenge of containing the Colts’ potent offense, spearheaded by the standout duo of Daniel Jones and Anthony Richardson.

Advertisement

Who is replacing Murray today for Cardinals vs Colts?

Jacoby Brissett is stepping in for Kyler Murray today. In his debut start this season, Brissett has the chance to impress and demonstrate to his former team the depth of his capabilities and what he can offer.

With this scenario, fans anticipate a distinct matchup dynamic, as the Cardinals adjust to playing without their star quarterback and the Colts aim to solidify their playoff aspirations with another victory.

Advertisement
ALSO READ
Colts clarify Daniel Jones’ future before 2026 free agency amid Anthony Richardson QB1 competition
NFL

Colts clarify Daniel Jones’ future before 2026 free agency amid Anthony Richardson QB1 competition

Most consecutive wins in NFL: The longest winning streaks ever
NFL

Most consecutive wins in NFL: The longest winning streaks ever

Colts free agents in 2026: Daniel Jones and other players out of contract in Indianapolis
NFL

Colts free agents in 2026: Daniel Jones and other players out of contract in Indianapolis

Colts owner offers intriguing insight into Anthony Richardson vs. Daniel Jones QB battle
NFL

Colts owner offers intriguing insight into Anthony Richardson vs. Daniel Jones QB battle

Better Collective Logo