Detroit Lions and San Francisco 49ers meet in Week 1 of the 2021 NFL season. This game will be held at Ford Field on September 12 at 1:00 PM (ET). Here is all the related information about this National Football League game including the preview, storylines, predictions, odds and how to watch in the US.

Matt Patricia has finally left and the Lions feel free and ready to start a new season with Dan Campbell as head coach and Jared Goff as the starting quarterback. Goff's experience with the Rams will surely go a long way for this new season.

The San Francisco 49ers are thinking about the negative things that could happen in the season to avoid bad results like in the past. One of the first things they have in mind is the quarterback backups in case Jimmy is injured in the first weeks of the 2021 NFL season.


Detroit Lions vs San Francisco 49ers: Match Information

Date: Sunday, September 12, 2021.
Time: 1:00 PM (ET)
Location: Ford Field, Detroit, Michigan.

Detroit Lions vs San Francisco 49ers: Times by State in the US

ET: 1:00 PM
CT: 12:00 PM
MT: 11:00 AM
PT: 10:00 AM

Detroit Lions vs San Francisco 49ers: Storylines

The Detroit Lions seem to have everything ready for the new 2021 NFL season despite the fact that there are still doubts about Dan Campbell as head coach. The good news for them was the trade with the Rams for Jared Goff to join the team.

The 49ers had to settle for a negative result last season after losing Jimmy Garoppolo for most of the season to an injury. They finished the 2020 season with six wins and 10 losses. Nick Mullens was the starting quarterback but he is gone now.

The last game between them was in September 2018 and the 49ers won 30-27 in San Francisco, at that time the Lions were led by Matt Patricia. The 49ers have a positive record against the Tigers at 38-28-1 overall.


How To Watch Or Stream Live Free Detroit Lions vs San Francisco 49ers in the U.S.

The NFL is available on Television, Radio and Live Streaming on the Internet, this and other games will be broadcast in the United States by: Fox, Fox App, NFL Game Pass. Don't forget to download the app to watch the game on your smartphone.

Detroit Lions vs San Francisco 49ers: Predictions And Odds

Detroit Lions are underdogs at home with +8.5 ATS and +315 moneyline at FanDuel. They are underdogs because of the new head coach and the weak offense. San Francisco 49ers are favorites for this game with -8.5 and -400 moneyline. The totals is offered at 45.5 points. The best pick for this NFL game is: Over 45.5

Detroit Lions -+8.5 / +315
Totals O/U 45.5
San Francisco 49ers -8.5 / -400

* Odds via FanDuel